Simulation and physical validation of triply periodic minimal surfaces-based scaffolds for biomedical applications (June 2024)

This paper was presented at the June 2024 NAFEMs Conference. NAFEMS is the International Association for the Engineering Modelling, Analysis and Simulation Community.

Metallic scaffolds are used as implants to help heal bones. Sheet-based Triply
Periodic Minimal Surfaces (TPMS) are of interest due to their high surface-to-volume ratio (S/V), customisable stiffness, and can be realised using Additive Manufacturing (AM). Other studies investigate porosity and pore size of scaffolds but they frequently overlook S/V, which is critical for cellular response. Additionally, the limitation of AM (esp. Selective Laser Melting (SLM)) causes discrepancies between intended and actual physical and mechanical properties of those structures, and this also needs to be addressed. This work investigates three types of TPMS scaffolds made in pure Titanium, with an emphasis on design vs manufactured differences and the significance of S/V. As-designed scaffolds reported 70-75% porosity and 25-35 cm-1 S/V, and stiffness was measured using finite element analysis (FEA) at 6.7-9.3 GPa. The manufactured scaffolds had 59-70% porosity and 33-42 cm-1 S/V. Laboratory compression testing revealed an effective Young’s modulus of 5-9 GPa, comparable to bone. Image-based simulation method was also employed on the built samples which reported the stiffness range of 8.3-16.6 GPa, overestimating it by 57%. It is hypothesised that these discrepancies stem from the secondary roughness deposited on the scaffold walls during SLM, causing reduction in porosity yet not contributing to structure’s strength. The cyber physical validation methods presented are a good way to quantify these
discrepancies, allowing feedback to the design stages for more predictable as manufactured structures.

https://www.nafems.org/publications/resource_center/uk24_ext_abs_18